Scale-up Crystallization and Particle Engineering

Avista Pharma’s scale-up crystallization service is aimed at developing a bench scale process into a robust procedure that can easily be transferred to plant. Avista Pharma aims to deliver an efficient process that yields batches of API that exhibit consistent, and optimized, physical and bulk properties. These properties include among others:


  • Consistent polymorphic form
  • Optimized particle size distribution
  • Efficient isolation and drying
  • Consistent and optimized particle morphology


Our crystallization engineers use the latest engineering software and methodology to understand how bench scale processes will perform on much larger scales. Further, using our expertise in statistical design and modeling, our engineers are able to test the robustness of developed crystallizations.


Overall, by providing a solid bridge between the bench and the plant, Avista Pharma offers a fast, low risk route to larger scale API production.